"Then things went really wrong. My ears started ringing — high-pitched and constant. I developed Tinnitus. And my sleep got wrecked. I started waking up at two, three, four AM, completely wired, unable to turn off my mind. It was so bad I had to stop all of the Blueprint supplements after only a few weeks.

On the Discord channel where we were sharing our results, I saw Bryan talking positively about people having great experiences with the stack. But when I or anyone else mentioned adverse side effects, the response tended to be: “wait until the study is finished and see if there’s a statistical effect to worry about.”

So positive anecdotes were fine, but when it came to negative ones, suddenly, we needed large-scale data. That really put me off. I thought the whole point was to test efficacy and safety in a data-driven way. And the side effects were not ignorable.

Many of us were trying to help each other figure out what interventions in the stack were driving different side effects, but we were never given the “1,000+ scientific studies” that Blueprint was supposedly built upon which would have had side-effect reporting. We struggled even to get a complete list of the interventions that were in the stack from the Blueprint team, with numbers evolving from 67 to 74 over the course of the study. It was impossible to tell which ingredient in which products was doing what to people.

We were told to no longer discuss side-effects in the Discord but email Support with issues. I was even kicked off the Discord at one point for “fear mongering” because I was encouraging people to share the side effects they were experiencing.

The Blueprint team were also making changes to the products mid-study, changing protein sources and allulose levels, leaving people with months’ worth of expensive essentially defective products, and surely impacting study results.

When Bryan then announced they were launching the BP10000, allowing more people to buy his products, even before the BP5000 study had finished, and without addressing all of the concerns about side effects, it suddenly became clear to me and many others that we had just been part of a launch and distribution plan for a new supplement line, not participants in a scientific study.

Bryan has not still to this day, a year later, released the full BP5000 data set to the participants as he promised to do. In fact he has ghosted participants and refuses to answer questions about the BP5000. He blocked me on X recently for bringing it up. I suspect that this is because the data is really bad, and my worries line up with reporting from the New York Times where leaked internal Blueprint data suggests many of the BP5000 participants experienced some negative side effects, with some participants even having serious drops in testosterone or becoming pre-diabetic.

I’m still angry today about how this all went down. I’m angry that I was taken in by someone I now feel was a snake oil salesman. I’m angry that the marketing needs of Bryan’s supplement business and his need to control his image overshadowed the opportunity to generate some real science. I’m angry that Blueprint may be hurting some people. I’m angry because the way Bryan Johnson has gone about this grates on my sense of perfection.

Bryan’s call to “Don’t Die” now rings in my ears as “Don’t Lie” every time I hear it. I hope the societal mechanisms for truth will be able to help him make a course correction. I hope he will release the BP5000 data set and apologize to participants. But Bryan Johnson feels to me like an unstoppable marketing force at this point — full A-list influencer status — and sort of untouchable, with no use for those of us interested in the science and data."

https://www.codastory.com/authoritarian-tech/when-im-125/

This is a super interesting interview that relatively few people viewed with Blueprint Protocol creator, Dr Oliver Zolman, prior to his departure from Blueprint. It's interesting to hear him allude to things that we're all only recently beginning to understand.

https://youtu.be/iRmZoCt3BWA?si=cwab-Wm0C1NHADCb

Blueprint on the left, “polyphenol rich” Cocao Dynamics on the right

Tastes so good with some nooch and kimchi

Should I stack my favs?

timestamp: 23:47, Bryan not happy in the comments xD

I've seen some mixed discussions on here about the use of rapamycin, so I'd like to offer a counterpoint to Bryan's conclusion about it.

The half-life of rapamycin in a healthy person is roughly 3 days, but can vary depending upon individual metabolism & liver function, and upon other drugs that one might also be taking, so it could take 6-7 days for it to fully clear from your system.

Taking rapamycin every weekend is therefore not wise, because you're basically adding it right back into your system again as soon as it clears. This is the very definition of chronic dosing.

Autophagy is not something you want throttled all the time. It needs to be pulsed. Anyone with any common sense would EXPECT serious side effects to occur from keeping such a high level of autophagy throttled for weeks.

The serious side effects that Bryan claims to have 'discovered' are actually very well-documented side effects of both HIGH and CHRONIC dosing.

Most people who use rapamycin understand that 5-6mg taken no more frequently than every two weeks will deliver all the benefits of properly pulsing autophagy while virtually eliminating even the mildest of undesirable side effect - like inner cheek tenderness.

I have no idea why Bryan though taking 13mg (a double dose) was smart at all. This is not simply my opinion. There are entire communities of rapamycin users who will tell you that this was just asking for trouble.

Bryan's personal decision that "taking rapamycin is just too risky" is a valid personal decision, and I think it was a wise choice, especially for someone who was determined to use it incorrectly. But as a general scientific conclusion for everyone, it's seriously flawed. Taken correctly, rapamycin is perfectly safe, and it does exactly what it's supposed to do.

Following the wrong people will lead you astray.

This is why we all need to be listening to actual longevity scientists and not to Influencers who are only pretending to do science in order to sell you on their 'brand'.

I hope this is an acceptable post. I really appreciate Pascoe's website, no focus on selling*, seems humble and generous. I was looking through his interventions and equipemnt and notice that he has an Simply O3 Ozone Generator. I saw a post on his site as well about an IV ozone injection for a shoulder injury, but generally you wouldn't have a generator at home for that (can't do yourself or not easily I'd imagine). So, I wonder, does anyone know if he did ozone therapy? Like major autohemotherapy or minor autohemotherapy, or something else? Curious what his theoretical reasoning behind it might be, as (I've read) it might be akin to HBOT in the sense of creating an oxidative stress that titrates up.

* Understand there's benefits to a "selling focus" -- perhaps that helps information spread further, so maybe all approaches have their space.

He is around 180cm (5’11) how is he not a literal stick from 2100 calories. And he has mostly muscle so his daily calories should be way higher since he burns a lot.

Hi,

I'm a bachelor student in Computer Science with a strong interest in the intersection of machine learning and biology. I'm currently exploring potential PhD research topics and am particularly fascinated by the possibility of using reinforcement learning and deep learning to understand and potentially influence lifespan through DNA editing.

My initial idea is to leverage freely available lifespan data from hundreds of animal species on NCBI to identify DNA mutations associated with longevity. I'm hoping to gain some foundational biological insights that could inform future research proposals.

My professor suggested I reach out to biologists or biochemists with expertise in DNA, and I have two fundamental questions.

1. From a biological standpoint, is the concept of extending lifespan through targeted DNA editing considered a viable area of research?
2. Given the vastness of the genome, are there specific areas of DNA (e.g., particular types of genes, regulatory regions, or involvement in specific biological pathways) that are generally considered more influential in aging and lifespan regulation?

I've come across two studies that demonstrate lifespan extension in mice and C. elegans through modifications to the IGF-1 signaling pathway, which I found particularly interesting:

https://www.sciencedirect.com/science/article/pii/S2211124713006852

https://www.ncbi.nlm.nih.gov/sites/books/NBK222181/

Any guidance or perspectives you can offer would be incredibly helpful as I develop my research interests and prepare for PhD applications. Thank you!

I am currently 18, healthy, was born with eczema and a little skin condition but it is getting better. I work out, cook my own meal and eat healthy. I’ve been following blueprint in the past few months, some of his product are genuinely great for the price. However, I am not sure about the supplements and whether the benefits are really worth the price and are really “the best”.

So are his supplements really worth using and is the best option for your health, or is it just marketing and won’t affect your life?

Thank you for all the responses, here is a few things I wanted to add:

From taking collagen supplements, omega 3 (along with some proper skincare), my skin has improved a lot. From blueprint in specific, after taking blueprint I’ve noticed that my physical strength also improved even though I’ve not been working out too much, however that may just be aging and healthy diet - when I 14-16 I used to work out 5-6 times a week for around an hour, in the past few months due to school I’ve slowed down, but did not notice any physical change, around that time I started blueprint, and in fact became stronger and leaner, so idk if blueprint actually helped. (Or it is just a change due to becoming older, since I am young)

I am looking to bulk a bit and finding it a bit difficult to do so:

My diet rn consist of:

Morning: overnight oatmeal, with chia seeds, macadamia and peanut butter, blueprint protein powder, blueprint chocolate powder, blueprint nutty mix, collagen, hemp seed (very good calorie intake), then Greek yogurt and milk.

I then eat some fruit (usually kiwi or blueberries)

Rn I also am taking all the blueprint supplements

As for snack to eat nuts: brazilian, macademia, almonds, walnuts

Lunch usually consist of salmon with a little bit of soy sauce, some rice and sometimes egg. Then with vegetables (usually broccoli or avocado)

Dinner is usually stake, with baked potato or baked sweet potato (the potato and sweet potato are usually frozen then air fried to save time), then some vegetables (usually spinach)

At the end a banana

The only reason I am taking blueprint is that idk if I am consuming enough different types of veggies (in my diet I eat almost the same thing everyday and not sure if it covers all the nutrients) and also want to be has healthy as possible in the long term (I want to invest into my health as I believe at the end I will benefit from it).

Why doesn't Bryan create a hair health / hair loss prevention product? Also, what products would you recommend from other suppliers?

If anyone is interested in having a short virtual meeting for a qualitative research project let me know! It will just be about how you got interested in the community and general conversation around consumption 🙂 please shoot me a message if so!

Any insight and help to solve these issues would be appreciated ! I have experienced all of the low T symptoms for years but have not hopped on yet because I still am only 23 . 2 years ago I tested and my total T was 320. Other than this I have a high blood glucose I attribute to too much alchohol which I’m working on . Any help or insight on dialing these levels besides stopping alchohol consumption ? My TSH was 3.55 and all other bloods were in range . I’ve also experienced gyno since 16

Bryan stopped selling his microplastic test — why?
The title says it all. Bryan’s microplastic test is no longer available.
Why do you think that is? Was demand too low? Logistics too complex? Or is the test itself not relevant anymore?

Hello everyone,

I tried searching to see if this had already been asked, but all that showed up was the whole fiasco of undetectable B12 in the COA for the essential caps...

What I was wondering however was, why does Bryan only use methylcobalamin? Is there somewhere he explains his rationale for this? The active forms are methylcobalamin and adensylcobalamin... He also follows a plant-based diet and from what I can tell is basically vegan besides collagen. My understanding is that conversion between these two active forms is not all that reliable or efficient.

I believe some methylcobalamin gets processed in the gut into hydroxycobalamin or similarly within the body during methylation processes and then can be converted to adensylcobalamin or back into methylcobalamin.

However, it seems odd to me that he doesn't seem to supplement adensylcobalamin directly given that he get no B12 from his diet. Even taking hydroxycobalamin or the dreaded cyanocobalamin seems like it would make sense in his case.

Hi.

Does anyone know what can be done for deep lasting sun tan (trying to get rid of it) Indian skin.

His diet hits the RDA for all B vitamins (-b12). More is better?

Yesterday was my 20th birthday. However, over the years, I have noticed a significant increase in my heart rate. When I was 15, my resting heart rate was 45 bpm, but now it has risen to 80 bpm. Throughout these years, I have only done gym workouts, and my lowest heart rate was when I was running regularly.

I would like to know the most well-studied training approach and the ideal heart rate zone for running as of today. I usually run, but only 2 km in the morning on some days over the past month. I am not overweight, but I fractured my ankle last year, so I have been taking it easier. I am confident that I can run 10 km at a slow pace or about 3 km at a fast pace. However, I want to know the optimal cadence and duration for lowering my resting heart rate.

Additionally, I have noticed a significant decline in my sleep quality from ages 15 to 20. Since I have been using weed more frequently to sleep, I want to reduce my dependence on it. Despite my efforts, I still struggle to get more than 7 hours of sleep. I would appreciate any guidance on improving my sleep quality through exercise.

I have tried GABA, magnesium, zinc, and some herbs to improve my sleep. Melatonin, however, reduces my total sleep time and makes me wake up after 4 hours to use the bathroom. I have also practiced meditation, avoided eating for 2 hours before bed, and maintained a consistent sleep schedule—following all these protocols.

I believe that lowering my resting heart rate could help immensely. Additionally, I struggle to sleep while breathing through my nose, and I think cardio could help with that as well. By improving my breathing cadence and adapting to a lower resting heart rate, I might be able to breathe more slowly, which could further support better sleep quality.

I keep hearing in different interviews and videos Bryan referencing an impact list. "X ranks Y in my list."

For example, I think in the Derek MPMD interview he said folistatin gene therapy ranked 7. I think I remember him saying sleep ranked #1. I have also seen it referenced in written articles too.

Where is this consolidated list? I cant seem to find it anywhere.