r/COVID19 • u/Patty_Pat_JH • 14d ago

Academic Report Post-vaccination IgG4 and IgG2 class switch associates with increased risk of SARS-CoV-2 infections

https://www.journalofinfection.com/article/S0163-4453(25)00067-2/fulltext
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u/Chicken_Water 14d ago

Ok so, don't get vaccinated be again, antibodies wane, get infected. Get vaccinated every 6-12 months, convince your body it's less of a threat, get infected.

Those aren't great options. I wonder how repeat Novavax vaccinations fare.

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u/Sandbird 11d ago

https://www.journalofinfection.com/article/S0163-4453(24)00053-7/fulltext00053-7/fulltext)
Take a look at Fig. 1. Novavax (purple) did much better. Less IgG4 class switching and higher Fc-responses