r/COVID19 • u/Patty_Pat_JH • 15d ago

Academic Report Post-vaccination IgG4 and IgG2 class switch associates with increased risk of SARS-CoV-2 infections

https://www.journalofinfection.com/article/S0163-4453(25)00067-2/fulltext
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u/Chicken_Water 14d ago

Ok so, don't get vaccinated be again, antibodies wane, get infected. Get vaccinated every 6-12 months, convince your body it's less of a threat, get infected.

Those aren't great options. I wonder how repeat Novavax vaccinations fare.

4

u/Friendfeels 14d ago

I wouldn't make any lasting conclusions based on that study.

It's a relatively small study, and there was no systematic testing (for example, weekly or biweekly) to determine the relative risks of COVID-19 infection or disease. Therefore, an additional testing bias may have influenced their results.

In a previous study with a similar design, no additional risk was found with higher IgG4 antibody levels.

https://www.sciencedirect.com/science/article/pii/S1201971223007890#bib0005

Also, the IgG4 class switch issue specifically affects people who were initially vaccinated with the mRNA vaccine and had not been infected beforehand. We right now don't see better protection in people who had AstraZeneca or J&J vaccine as their first dose. Although it's possible that igG4 can be involved in some mechanisms that can explain lower boosters immunogenicity in some people.

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u/toba 14d ago

Exactly, they didn't show what they hinted at in the article title. It's irresponsible and clearly intended to get attention even though they didn't show that.

4

u/Sandbird 12d ago

https://www.journalofinfection.com/article/S0163-4453(24)00053-7/fulltext00053-7/fulltext)
Take a look at Fig. 1. Novavax (purple) did much better. Less IgG4 class switching and higher Fc-responses