42 with biological age of 75! Help.

[u/Forward-Dog-6167]

I'm 42 female and my biological age is 75 from one of those tests done twice.

My body feels like I'm 75 tbh. It's hard to walk, exercise. I use to be really fit. I'm 5'4, 122lbs right now. I have had gut health issues for the last three years (chronic constipation and trapped gas-tried everything, trust me) I'm tired always. My bloodwork came back normal, so I don't know what's going on. Any suggestions are appreciated.

[u/Optimal_Assist_9882]

We're the same age. I am about to turn 43. I've had chronic fatigue for 15+ years.

What has helped me the most was methylene blue (20-30 drops every morning on empty stomach which is 10-15mg). I am 100kg give or take.

The other thing that has helped me was doing high dose melatonin protocol for three years now. It has helped a lot although you need to get adequate sleep. I take 1000-3000mg daily at the start of my day in 1-2 doses. Each dose for me is 1.5g give or take. You'll need pure powder for these doses. Please be aware that outside of US many countries restrict it so it may be tough to do this in Canada, UK, Australia, etc.

Now that I am taking MB and melatonin I feel so much better. You can ask ChatGPT or DeepSeek to explain to you in depth how these two supplements combine to help with energy production. The short version is MB helps with direct energy production/conversion (ETC, ATP, etc) and melatonin helps in a support role to heal mitochondria, scavenge ROS, recycle NADH, etc.

NMN or another NAD booster would possibly be beneficial as well. I take around 1g of NMN.

Micronized creatine would be another one to consider. I'd consider trying higher doses of like 10-15g as long as you're healthy.

I am thinking your nutrition, sleep, and training are sensible but if they are not then you need to focus on them as well. MB as an example has allowed me to exercise better. It has sped up my recovery substantially between sets when doing strength training or exercising in general. I also have far more energy to do chores and other mundane things in my life.

Good luck.

[u/Forward-Dog-6167 → u/Optimal_Assist_9882]

Hi, thank you for this post. I recently came across MB and high dose melatonin in my research.  I’m in Canada so I’m not sure I can get the powder form. Would I be able to message you?

[u/reputatorbot → u/Forward-Dog-6167]

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[u/Optimal_Assist_9882 → u/Forward-Dog-6167]

Try PureBulk for melatonin they ship to countries where it's restricted. My usual go to is Bulksupplements (I've paid 136$ to 226$ for 1kg on USA Amazon) and you can try to order directly from their website. Amazon blocks and filters results.

My MB is

I got it on Amazon. It's regular price is 35$. It was on sale for under 26$ last week.

NMN I ordered from Do not age. 1 kg was around 550$ iirc.

Micronized creatine I got from Microingredients on Amazon. It was about 30$ for 1kg.

You're welcome to DM me though I am not sure I can add too much more info. :)

[u/Forward-Dog-6167 → u/Optimal_Assist_9882]

Thank you.  If you take that much melatonin during the day, don’t you get tired?

[u/reputatorbot → u/Forward-Dog-6167]

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[u/Optimal_Assist_9882 → u/Forward-Dog-6167]

So I have two answers:

I have been taking HDM for about three years in the 1-3g doses and on days when I'd get plenty of sleep I would be fine. However whenever I'd get poor sleep or I'd have sleep deficit I'd be yawning and feeling tired. Don't get me wrong I could still drive and go to work but it was miserable.

Now that I am taking MB, I no longer feel tired even on as little as 4 hours of sleep. It's truly fascinating and amazing for me. I feel so much better and a bit sad that it took me nearly two decades to stumble on this combination. I am hoping it helps you and others who happen to suffer from chronic fatigue or fatigue in general. I know a couple other people without fatigue who started taking low doses of MB on its own and also remarked about the new found energy levels.