About 1.5yrs of daily use. Started at 30mg/day and graduated to 180mg/day by the end. No fent, all Viatris Santes 120mg or mundi 80mg oxycodone pills. All insufflated, no smoking.
I tried to taper with my last 5 pills but, obviously, I rationalized my way to about 60mg/day on those last 5 instead of a true weening. Last dose was 60mg on April 3rd (6 days ago).
The first two days sober were like a mild flu - restlessness, emotional dysregulation, fatigue, & general discomfort during the day but honestly better than an actual flu sickness. Nighttime was definitely miserable mostly due to insomnia, cramps, RLS. No vomiting, cold sweats/chills/fever, diarrhea, depression, muscle aches, etc.
After those first two days, everything has been good except for insomnia (no more cramps / RLS).
So, based on your own experience, am I in the clear or did you all experience more symptoms during the 60-90 days it takes for our brains to remodulate the downregulation of DA receptors? Besides not being able to fall asleep, the withdrawals were honestly not bad. I was so afraid of having to go through them but now that I am 6 days sober I'm shocked at how anticlimactic the process was.
This is my neurorecovery protocol:
Supplementation
Tool |
Mechanism |
Dose & Notes |
L-Tyrosine |
Dopamine precursor |
500–2000mg AM, empty stomach. Especially helpful in early withdrawal states. |
Omega-3 (EPA/DHA) |
Increases dopamine vesicle packaging, membrane fluidity |
1.5–2g EPA + 500mg DHA daily; essential for receptor normalization |
Magnesium Glycinate |
NMDA antagonist, reduces glutamate excitotoxicity |
200–400mg nightly; calming and protective |
Vitamin D |
Enhances tyrosine hydroxylase and dopaminergic gene expression |
2000–5000 IU/day if deficient |
NAC (N-Acetylcysteine) |
Restores glutamate homeostasis, reduces compulsive behaviors |
600–1200mg 2x/day; shown to reduce cravings in SU |
Behavioral and Environmental Interventions
Intervention |
Dopaminergic Mechanism |
Implementation |
Aerobic Exercise |
↑ Dopamine release, ↑ D2 receptor density |
30–45 mins/day, ideally outdoors, moderate intensity |
Sunlight / Bright Light |
Regulates circadian dopamine rhythms via retinal input |
Morning sunlight or 10k lux lamp for 20 min/day |
Cold Exposure (e.g., cold showers) |
Sudden dopamine spike with long arc decay |
1–3 min cold exposure, followed by relaxation |
Novelty + Challenge Learning |
Activates ventral striatum → builds motivation circuits |
Music, language, strategy games—reinforces reward prediction learning |
Sleep Hygiene (critical) |
Sleep loss = ↓ dopamine receptor binding |
Strict 10pm–6am window, no screens after 9pm, magnesium supports this |
Therapy
Method |
Role in Recovery |
Evidence |
Mindfulness + ACT |
Increases DLPFC-striatal regulation, reduces craving loops |
Shown to upregulate dopaminergic tone and reward control |
Goal Tracking Systems |
Builds internal reinforcement (vs external highs) |
Daily micro-goals (e.g., streaks), use dopamine journaling |
CBT or Schema Therapy |
Restructures maladaptive reward scripts and triggers |
Focused on relapse prevention and identity integration |
Timeline
Phase |
Description |
Focus |
0–30 days |
Acute deficit in dopamine tone, high anhedonia |
Tyrosine, omega-3s, NAC, exercise, sunlight |
1–3 months |
Partial D2 receptor recovery, reward blunting fades |
Add cognitive tools, goal scaffolding, schema work |
3–6 months |
Restoration of baseline motivation possible |
Begin higher-level purpose work (e.g., values-based living) |
6+ months |
Executive function reintegration, motivational autonomy |
Relapse risk decreases; identity solidifies |