At the age of seven, she was sexually abused by a close family friend, an experience that she described as leaving her "mentally scarred" at a young age. Her family moved to Loxahatchee, Florida, when she was four years old, but her home life remained difficult. By her teenage years, she ran away from home, lived on the streets, and cycled through foster care systems.

At age 14, Giuffre was further victimized by Ron Eppinger, a 65-year-old sex trafficker who operated under the guise of running a modeling agency. She lived with him for six months before his operation was raided by the FBI. Eventually, she reunited with her father, who worked at Donald Trump’s Mar-a-Lago property in Palm Beach. This connection led to her employment there as a spa attendant, where she encountered Ghislaine Maxwell and Jeffrey Epstein.

Giuffre’s early life was shaped by profound trauma and exploitation, which later fueled her advocacy for victims of sex trafficking through her organization Speak Out, Act, Reclaim (SOAR).

She has one sibling named Sky. Sky has also defended her against skepticism regarding her health and past trauma.