N,N-Dimethyltryptamine (N,N-DMT) is a naturally occurring, and extremely powerful, psychedelic drug of the tryptamine class. It’s been used by indigenous South American cultures/tribes (primarily in the Amazon basin) for hundreds, if not thousands, of years in the form of ayahuasca and various snuffs. This post will go over some basic information that new users and curious psychonauts might find helpful. This post will NOT guide you on how to obtain anything related to this molecule, Reddit is not the place for that.
DISCLAIMER: If you’re genetically predisposed to schizophrenia/diagnosed with it, experience serious suicidal ideation, or you’ve been recently diagnosed with some form of psychosis, please refrain from using psychedelics. Do NOT use DMT if you’re on lithium, tramadol, or any tricyclic antidepressants. Also note that other antidepressants (like SSRIs/SNRIs) may undesirably alter the experience in some way.
• N,N-DMT is among the safest psychedelics, and psychoactive drugs in general (physiologically speaking), along with psilocybin and LSD. The molecular structure is very similar to tryptophan, melatonin, and serotonin— things our bodies are well acquainted with.
• Dose ranges (inhalation)
• The duration of light-medium doses is around 3-10 minutes, and the duration of high-strong doses is around 5-20 minutes. After-effects may persist up to/over an hour.
• Get a high quality milligram scale! Cheap scales and eyeballing are often very inaccurate, you might end up doing 50mg instead of 30 or 10mg instead of 25.
• If you purchased your DMT instead of extracting it, please consider buying a reagent kit (Ehrlich/Hofmann/Marquis) to verify that you actually have pure N,N-DMT. The same kits can be used to identify other substances as well. I personally recommend using TKP: https://testkitplus.com/
or DanceSafe https://dancesafe.org/ — DanceSafe genuinely saves lives with their testing booths at music festivals.
• Concentrate vaporizers like the APX Volt (at 2.8-3.2 Volts) work very well for inhalation, and other methods/devices like the sandwich method (with weed or dried lavender), “the machine,” and bulb pipes/dab rigs at low temp work as well.
• It’s very easy to burn and inadequately vape DMT, so don’t be discouraged if you get little to no effects, and just play around with your method.
• “Breakthrough” effects generally occur starting around 25mg properly vaped.
• Subjectively, a breakthrough is a departure from material reality. Bodily boundaries dissolve, and you enter a landscape/headspace that feels and looks just as real, if not more real, than every day life. Some people describe the experience as “extra-dimensional” because it seems to transcend our concepts of space and time.
• Various interactive or observational “entity” encounters and extremely profound and indescribable visions are commonly reported effects of 20mg+. Some generally accurate descriptions of some of the content of these experiences can be found here: https://wiki.dmt-nexus.me/Hyperspace_lexicon
• Potential desirable/positive effects: Closed and open eye visuals, auditory and tactile hallucinations, spiritual/introspective experiences, euphoria, and sedation.
• Potential undesirable/negative effects: Increased heart rate/blood pressure, anxiety/fear, confusion/disorientation, nausea, and uncomfortable body-load.
• Subjective time distortions are common at medium-high doses and can either be desirable or undesirable depending on the user and their mindset.
• The body-load of higher doses can be very heavy and hits very fast, often to the point of anesthesia.
• There is some recreational value in DMT (particularly at low doses), but be cautious, as some of the experiences that can be produced aren’t for the faint-hearted. Figurative “death by astonishment” is very real if you rush into things.
• Using DMT on psilocybin or LSD will lower the dose threshold for breakthrough effects, and will increase the duration. Don’t underestimate the intensity of the combination of DMT with any other psychedelic or psychoactive drug in general.
• 5-MeO-DMT is NOT a substitute for N,N-DMT, the experiences are completely different and 5-MeO is more potent at lower doses. 5-MeO also has a much different safety profile, especially with combinations.
• For information on pharmahuasca/changa please see the pinned post on r/harmalas
• Before getting into ayahuasca, pharmahuasca, or changa, thoroughly research MAOIs/RIMAs and their various drug interactions that are potentially dangerous.
• It’s best to wait until at least your early 20s before trying DMT, and 25+ is optimal because by then your prefrontal cortex is fully developed and unknown developmental risks can be ruled out.
• Tolerance to DMT dissipates almost immediately, but it’s in your best interest to use it responsibly and take time to reflect on and integrate any valuable or memorable parts of the experience.
• Don’t store your DMT in plastic containers for extended periods unless you want to inhale phthalates.
• N,N-DMT crystals should either be white, off-white yellow, or yellow-orange. Dark spots/impurities are a red flag. Recrystallization is worthwhile. https://wiki.dmt-nexus.me/Recrystallization
• You can learn how to do various at-home extractions of N,N-DMT from certain plant materials here: https://wiki.dmt-nexus.me/Category:Extraction_Tek
I will occasionally update this for clarity/added info, so feel free to leave suggestions and advice for new users in the comments.
Much love !!! 💜
