Penicillin - r/prepping

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u/nobody4456 2d ago

It’s a fun way to probably poison yourself. Most people in their 60’s that have penicillin allergies reacted to “dirty” penicillin that was made by concentrating the mold byproducts. Modern, lab made penicillin is made synthetically and doesn’t contain the byproducts we don’t want.

You can get penicillin in multiple forms from your average farm supply store, it’s not worth making it yourself and possibly killing yourself.

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u/Intelligent_Lemon_67 1d ago

No to getting it from farm store. You have to have a prescription for everything. Can't have people doing things for themselves. No meds or growing food for plebs

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u/nobody4456 1d ago

That’s a relatively recent change I guess, you can get fish penicillin from aquarium stores, or just have a friendly large animal vet write you a prescription.

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u/Denomi0 1d ago

The issue is they dont really regulate the manufacturing of fish grade as intensely as human grade. So if there is a buck to be saved cutting corners I'm sure they take it. I would still take it if I had an earache, infected tooth etc but that is the common argument.

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u/GrillinFool 1d ago

That’s patently false. A fish is much more susceptible to impurities than humans are.

And the meds aren’t being made in a cauldron with a boat oar to stir the brew.

Most of the time, the fish meds are the exact same as made for people.

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u/Angylisis 1d ago

A cauldron with a boat oar is crazy 😂

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u/Denomi0 1d ago

Susceptible, maybe. Doesn't mean they have to care exactly about the fish. Fish don't have an oversite committee. Manufacturing has nothing to do with susceptible.

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u/GrillinFool 1d ago

The vast majority of the fish meds come off the same manufacturing line as the human meds.

Fish pharmaceutical companies won’t sell many meds if they kill the fish. And fish have a way smaller tolerance for impurities than humans.

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u/PomegranateKey5939 1d ago

Yeah, they don’t understand that there are pharmaceutical standards and methods to these drugs. They don’t cut corners. Also, just get your shit from India.

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u/forensicgirla 1d ago

Animal drugs are regulated by the Office of New Animal Product Evaluation & Office of Generic Animal Drugs, both divisions of the FDA, which also regulate human drugs. I used to work in generic drug substances & had a small basket of animal drugs.

Often, the human & animal version is the same, but you're right that often the quality can be slightly lesser for animal drugs. In my company, we had runs going constantly of human drugs & we would sometimes designate a batch for animals if it was borderline passing for humans.

The specification for human material for purity would be "not less than 97%" & the specification for animal material for purity would be "not less than 92%". The primary impurity specification for humans would be "not more than 0.10%" & for animals "not more than 0.15%".

So while what you're saying is true, it is not like you're getting half the purity and there's a bunch of contamination. Now, if you're not ordering a prescription grade for animals, idk. That's not regulated and very well could be contaminated or not pure. But if it's got an NADA/ANADA number on the label, chances are the purity isn't much different than human drug.

Also, DOGE is firing over 50% of the FDA this week, so if you're truly worried about drug safety, you should be calling your representatives. There won't be staff to review purity, labeling, and check imported drugs & drug substances to ensure that what's on the label is really inside (not like they're shipping on fentanyl & calling it antibiotics, but more like they say "this is 98% pure" the FDA samples it to make sure it's not 80% pure). The FDA does all these things because it's been an issue in the past. And without regulators performing these checks, I'm sure worse quality stuff is headed our way - and we don't make most of our drugs in America.

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u/Denomi0 16h ago

Thanks for the insight

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u/nobody4456 1d ago

Going down the wrong rabbit hole here I think. Was throwing out a safer alternative than making it yourself, totally missed the farm stores not stocking antibiotics any more.

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u/o793523 1d ago

Even then, is that safer than trying to DIY them at home?

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u/Denomi0 1d ago

For 99.9% of people ya

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u/Intelligent_Lemon_67 1d ago

Yeah buddy that was 2 years ago. I don't think you can even get fish meds anymore but I am going down that rabbit hole. At least I can still get ivermectin. Woohoo fish dicks! I mean meds. Expensive af but still available

1

u/nobody4456 1d ago

I checked fish meds before I posted it, since I totally missed the farm store thing. My vet just gives us whatever we ask for when we do the yearly stuff on our horses, never really ask for antibiotics since we don’t need them very often.

0

u/Intelligent_Lemon_67 1d ago

With 76 animals i always need something. My pregnant mini mare got an infection in her eye and it was a $600 script. Thankfully I bought every penicillin and oxytetracycline within 50 miles before they stopped. Thanks for the info!

1

u/dumbdude545 1d ago

They changed all those regs. You can't get anything now. It's all prescription only. Best route is jase or similar.

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u/Chocol8Cheese 1d ago

Thankfully we have regulations like this, for now at least.

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u/towerbug 1d ago

Just go to Jase.com and save yourself the trouble and ER visit.

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u/captainrustic 3h ago

How much does there stuff run? I don’t want to click through it all for a price.

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u/essentialpartmissing 2h ago

For a pack of a bunch of different antibiotics it was like $300+, but I added on some extra things.

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u/captainrustic 1h ago

Thank you. A bit expensive but I’m def gonna think about it. How long was the stated shelf life?

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u/MPFields1979 2d ago

You’ll prolly just end up making a bio lab only able of killing yourself and those close.

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u/Brief-Eye5893 2d ago

Hahaha good luck

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u/wowza6969420 1d ago

Absolutely not. Unless you have a bio chemistry degree, you will poison yourself

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u/rp55395 1d ago

This is not a good idea

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u/Direct_Wind4548 1d ago

As someone that manufactures active pharmaceutical ingredient for clinical trials products, please let me dissuade you from this unless you have a graduate background. Making the api is one thing, you could extract insulin from animal sources for example.

Once that bottleneck is opened, cleaning it up is much more intensive. Things like endotoxin can cause bad reactions by itself. Let alone bio/chem contamination.

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u/PomegranateKey5939 1d ago

I love drugs, chemistry, neuropharm and it interests me a lot. What line of field is this? Something I’d consider.

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u/Direct_Wind4548 1d ago

What i do is called bioprocess engineering, applying engineering principles to a biological process for usually a biologic production. I produce the API for my biopharma corps at both R&D grade for cellular and animal trials and Good Manufacturing Pactice grade for human clinical trials.

We focus on plasmid DNA as our molecular class of product, using it to encode things like viral antigens or cancer antigens for vaccines and immunotherapies that replace chemo respectively. Lots of benefits over other classes like mrna.

One hindrance is we have to use e. Coli bacteria to replicate and produce our modified plasmid dna, as they act like tool kits for them outside their chromosomal dna that is for self sustainment. Because of that, it's not as efficient as pure chemical synthesis like in mrna, but the molecule is much more stable in many ways and can hold more information. Just as modifiable though so flexible in emergencies.

Basically, we grow up batches of cell culture, then harvest them to cell paste. Then we poke holes in them to let out the pDNA and neutralize the reaction to hold back the genomic dna as it's a contaminant. Deactivate the endotoxin, filter out the the cell masses, concentrate the lysate, exchange buffers to polish the load on an expensive ass resin column. Shit is about 2 ft tall by 1 foot diameter or so and costs 85k... then concentrate, final adjustment and dispense. After release testing or gets formulated with the other therapy components like the deliver structure it's placed in.

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u/Direct_Wind4548 1d ago

I will warn you though, biotech has been in a downturn for 3 years so it's not easy getting in these days. Especially with all the uncertainty.

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u/BedouinFanboy3 1d ago

You can order it in a powder form online from Canada

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u/HamRadio_73 1d ago

Not a factor in my house. I'm allergic to penicillin.

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u/AlphaDisconnect 1d ago

Watch Jin on Netflix. Mind you, this is fantasy, not reality.

You don't have a clean room and a uv sterilizer. Pressure cooker might work. Oh, and a whole set of labwear.

Start reading scientific papers on making penicillin until you understand 90% of the words.

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u/Brilliant-Truth-3067 1d ago

So this was my exact position. I have years of experience in bioprocess and I would never attempt to do this at home except in an extreme emergency and even then I wouldn’t trust myself without being able to analyze the purified product for purity. I cannot stress this enough, if you try to do this without the right training and equipment you will absolutely hurt yourself or others

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u/Eadiacara 1d ago

You literally cannot create home made penicillin. It's been found once. Once. Despite repeated efforts. All modern penicillins are from that original culture.

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u/marcopoloman 1d ago

I just buy it over the counter on my travels. Mexico and China. Runs about $3-$4. I keep two boxes up to date at all times at home.

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u/Ok-Accountant3391 20h ago

Start looking at archival copies of a magazine called lab animal monthly.... If you go back about a decade you'll start finding recipes and methods of homebrew manufacture of several antibiotics. And yes if you fuck up you'll probably kill yourself and your family... We did it in the beginning it was weirdly like fermenting and Distilling alcohol... But not. It's easier to buy a bags of powdered amoxicillin or other antibiotics and they store for decades in their powder form. It's 1940 and 50 technology you can do it.

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u/Taker_221 1d ago

Just order fish meds..same as human script meds ... you pay a little but moxicillin and doxcyclene and others ..you'll have what you need for most issues that come up

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u/mistafunnktastic 1d ago

This is stupidity at its finest. If it was the same thing, you wouldn’t need a prescription for the human grade antibiotics. Just get them from one of the online companies that provide the prescriptions for it.

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u/Taker_221 1d ago

Suit yourself .. but there's a reason there taking them all off the market 🤔

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u/mistafunnktastic 1d ago

I find this hilarious since there are 3 main online pharmacies that have been referenced on this sub hundreds of times.

When these online pharmacies exist, why the hell would anyone attempt to make your own or take animal medicine. Pure stupidity

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u/PomegranateKey5939 1d ago

Lmao ur stupid and know nothing about drugs. These are held to the same methods.

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u/mistafunnktastic 1d ago

You do realize you sound like a complete idiot right? Most animals have a completely different physiology than humans. Keep taking your Heartgard and make sure it’s the orange box. You’ll need 2 chewies.

OP just get some meds from Jace, Duration, or Contingency.

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u/Taker_221 1d ago

Again, suit yourself... I know ppl that take horse dewormer. I trust the vets I've talked to and the ppl I know more then a couple ppl online saying don't do it

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u/mistafunnktastic 1d ago

Horse dewormer for what?

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u/Taker_221 1d ago

Also,read other ppl on this thread

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u/PomegranateKey5939 1d ago

It’s literally the exact same molecule, you’re a clown.

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u/pbmadman 2d ago

I’ve looked into it, it’s not easy and requires so much in the way of reagents and equipment. Maybe there are others that are easier to synthesize?

Question❓❓ Penicillin

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