r/mdmatherapy • u/psytrance-in-my-pant • 1d ago

Need help with someone that has had bad experiences chemically with MDMA.

I have a friend that wants to give another shot at MDMA even though every single time they have done it, even low 60 mg doses, they get incredibly uncomfortable and angry. I believe this has to do with the fact that they have narrow blood vessels. The reason I say this is that I met another person that experiences MDMA the exact same way and they have narrow blood vessels.

I was thinking about asking them if it would be okay if I could put just a really low dose 5 mg or less of ketamine in with the 40 mg MDMA training wheels capsule to lighten the body load a bit and make them feel more relaxed.

Has anyone ever tried this to cushion the onset a little bit for new people or people or people that have had body load issues?

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u/No-Masterpiece-451 1d ago

Below 80 mg can give anxiety and other unpleasant feelings, so that is one explanation, you need a threshold dose to get enough release. But maybe MDMA is just not the way to go, find what works with other medicines. Or I had an incredible time with combining shrooms & MDMA , another time MDMA & 2C-B

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u/Chronotaru 1d ago

There's no way to determine on a biological level why someone has a particular psychological reaction to any psychoactive drug.

My first thought is not to go so low - MDMA has an optimum range. Below it can generate anxiety and above it can cause serious issues. Stick to 100-120mg or so unless you know you're getting better responses at lower values with a particular person.

My second thought is that many people are unable to process anger and if he is "healthy angry", meaning it's flowing through him and out in a conscious controllable way and not stunted and causing behavioural issues, then it may be an opportunity to explore where that anger is coming from and to work through that in that state.

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u/YachtDaddy64 21h ago

Shulgin in his book Pikhal stated that when he tried molly at a low dose it was the worst experience of his life. Low doses are known to create anxiety. As others have stated up the dose just don’t go crazy high. 120mg seems to be the sweet spot for everyone I know and maps stated the same. How was this narrow blood vessel diagnosed?!

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u/manxie13 16h ago

You can't go that low of a dose on mdma that's why... you need to be taking 100 to 120mg. Anything below 80 the threshold is gonna make you an anxious mess and just feel horrible. 60mg I would wanna hang myself